... LiAlH 4 is a common ingredient in the laboratory for the reduction of not only acids but many other classes of compounds. A General Preparation of Polyfunctional Benzylic Zinc Organometallic Compounds. They are much less reactive than either RLi or RMgX to aldehydes and ketones. Céline Boucley, Gérard Cahiez, Silvia Carini, Vanda Cerè, Mauro Comes-Franchini, Paul Knochel, Salvatore Pollicino, Alfredo Ricci. Asymmetric Activation of Chiral Alkoxyzinc Catalysts by Chiral Nitrogen Activators for Dialkylzinc Addition to Aldehydes: Super High-Throughput Screening of Combinatorial Libraries of Chiral Ligands and Activators by HPLC-CD/UV and HPLC-OR/RIU Systems. Chiral aminonaphthol-catalyzed enantioselective carbonyl addition of diethylzinc to aromatic aldehydes high-throughput screened by CD-HPLC analysis. Björn Greve, Peter Imming, Stefan Laufer. Synthesis and reactions of a novel chlorostannane resin: coupling with functionalized organozinc halides. However, advantageously, such solvent is not removed prior to contact with the liquid. Highly stereoselective palladium-catalyzed coupling reactions of captodative olefins acetylvinyl arenecarboxylates. Enantioselective Catalytic Conjugate Addition of Dialkylzinc Reagents using Copper–Phosphoramidite Complexes; Ligand Variation and Non-linear Effects. B. H. Lipshutz, M. R. Wood, R. Tirado. product HNMR & Mass R weight (g) ee (%) a20 Spectra o-CF3 1.5 44 (+) CHOH, 1H, 6.20s; ArH7.1-7.60, 9H 252, 233, 214, 195, 183, 166, 153, 105, 77, 51 m-CF3 1.7 56 +7.57 CHOH, 1H, 5.78s; c = 2.4 ArH7.1-7.65, 9H 252, 233, 214, 195, 183, 166, 153, 105, 77, 51 p-CF3 1.8 66 +33.5 CHOH, 1H, 5.78s; ArH7.26 5H c = 1.5 ArH, AB, 7.45, 4H, J = 8.46, 9.83 Hz 252, 233, 214, 195, 183, 166, 153, 105, 77, 51, Anhydrous zinc bromide (10.45 g) was charged to a dry, stirred 250 ml flask filled with nitrogen. Yuichi Kobayashi, Kengo Watatani, Yuko Tokoro. Norio Sakai, Junichi Asano, Yuki Kawada, Takeo Konakahara. Chiral o-hydroxyarylphosphine oxides: a new family of efficient catalysts in asymmetric addition of diethylzinc to benzaldehyde. Bernd Goldfuss, Melanie Steigelmann, Frank Rominger. Soc. Versleijen, Albert M. van Leusen, Ben L. Feringa. : Anhydrous zinc bromide (8.6 g) was charged to a dry, stirred, 250 ml flask filled with nitrogen. Alkyl Chalcogenides: Oxygen-based Functional Groups. Beispielreaktion Rieke-Zink V2.svg 713 × 223; 10 KB. Biaryl and Aryl Ketone Synthesis via Pd-Catalyzed Decarboxylative Coupling of Carboxylate Salts with Aryl Triflates. To purify the organozinc compound, it has been proposed in the case of aromatic organozinc compounds, and when the other metal is magnesium, to precipitate its halide by adding 1,4-dioxan, (e.g. Roberto Melgar-Fernández, Rodrigo González-Olvera, J. Luis Olivares-Romero, Vianney González-López, Leticia Romero-Ponce, María del Refugio Ramírez-Zárate, Patricia Demare, Ignacio Regla, Eusebio Juaristi. To the pale yellow filtrates the D(+)DENE was added against a counter-current of nitrogen. Asymmetric dialkyl ethers can also be employed, such as t-butylmethylether. Hirotada Kakiya, Hiroshi Shinokubo, Koichiro Oshima. Polyfunctional Zinc, Cobalt and Iron Organometallics Prepared by Electrosynthesis. Chemoselective acylation of some oxidofunctionalised organolithium compounds. (1E,3E,5Z)-1,6-Dibromohexa-1,3,5-triene: regio- and stereocontrolled mono pallado-catalysed cross-coupling reactions. -arylation of imidazoles. Igor Kazmierski, Corinne Gosmini, Jean-Marc Paris, Jacques Périchon. The aromatic moiety may be a heteroaromatic group, especially a furyl, pyridyl, quinolyl or thienyl group; a metalloaromatic group such as ferrocenyl; or an araliphatic group, particularly a benzyl group. Kevin E.B. Rosanne P.A. The Fluoride-Free Transmetalation of Organosilanes to Gold. Koichi Mikami, Rémy Angelaud, Kuiling Ding, Akihiro Ishii, Akito Tanaka, Naotaka Sawada, Kenichi Kudo, Masaaki Senda. Michael J. Cowley, Kai Abersfelder, Andrew J. P. White, Moumita Majumdar, David Scheschkewitz. New Preparations and Reactions of Organozinc Reagents. The organic groups in the organozinc compound may carry one or more substituents. If the reagent is in solution, the solvent is preferably one or more of the liquids defined above. Dan Feng Huang, Hai Feng Wang, Chang Ming Xu, Teng Niu, Yu Lai Hu. Metal Complexes as Catalysts for CC Cross-coupling Reactions. Sven Schröter, Christoph Stock, Thorsten Bach. The resulting solutions of diphenylzinc were reacted with substituted benzaldehydes and the products analysed for-yield and enantiomeric excess. A preferred process according to the third aspect of the present invention comprises reacting a prochiral aldehyde or aldimine with either: a) an organozinc compound prepared by the process of the first aspect of the present invention in the presence of a scalemic chelating compound catalytic for the reaction, preferably an aminoalcohol, diamine, aminothiol or a diol, in which the chelating groups are separated by 2 or 3 carbon atoms; or. Soo-Gyun Roh, Yu-Chul Park, Dong-Kyu Park, Tae-Jeong Kim, Jong Hwa Jeong. “Black Swan Events” in Organic Synthesis. Ingo Klement, Mario Rottländer, Charles E. Tucker, Tahir N. Majid, Paul Knochel, Patricia Venegas, Gérard Cahiez. Summary. 2 ( Sebastiaan (Bas) A. M. W. van den Broek, Jaap G. H. Lemmers, Floris L. van Delft, Floris P. J. T. Rutjes. Jun Wen, Ji Zhang, Shan-Yong Chen, Jing Li, Xiao-Qi Yu. )- and (2 George W. Kabalka, John T. Maddox, Ekaterini Bogas, David Tejedor, Emily J. Ross.