Pablo M. Perez Garcia, Thomas Di Franco, Alessio Orsino, Peng Ren, and Xile Hu . Avishek Paul, Mark D. Smith, and Aaron K. Vannucci . With alkyl coupling partners, these reactions typically run into two problems within the catalytic cycle. iii Synthesis and Reactivity of Pyridine(diimine) Molybdenum Olefin Complexes: Ethylene Dimerization and Alkene Dehydrogenation. Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals. Bis-dienes were also effective additives for the Ni-catalyzed cross-coupling reaction of organozinc reagents with alkyl halides. 0 Yoshinori Aihara, Jendrik Wuelbern, Naoto Chatani. From Dimethylamine to Pyrrolidine: The Development of an Improved Nickel Pincer Complex for Cross-Coupling of Nonactivated Secondary Alkyl Halides. compound which contains a terminal hydrogen atoms connected to a alkyne C–C and C–X coupling reactions of unactivated alkyl electrophiles using copper catalysis. Nickel-Catalyzed Cross-Coupling Reactions. Copper-catalyzed cross-coupling reactions of non-activated primary, secondary or tertiary alkyl chlorides with phenylmagnesium bromide. Naveen Kosar, Khurshid Ayub, Mazhar A. Gilani, Faheem Shah, Tariq Mahmood. If moisture or water is contact with grignard, grignard is destroyed. i-PrI Acceleration of Negishi Cross-Coupling Reactions. and Pazhamalai Anbarasan, Helfried Neumann, Matthias Beller. Copyright © 2015 Elsevier Ltd. All rights reserved. Bis(imidate)palladium(ii) complexes with labile ligands. Nickel-Mediated Inter- and Intramolecular Reductive Cross-Coupling of Unactivated Alkyl Bromides and Aryl Iodides at Room Temperature. Bidentate Hydroxyalkyl NHC Ligands for the Copper-Catalyzed Asymmetric Allylic Substitution of Allyl Phosphates with Grignard Reagents. Jonathan A. Brekan, Dmitri Chernyak, Kolby L. White, Karl A. Scheidt. Brenda A. Frazier, Peter T. Wolczanski and Emil B. Lobkovsky. Susan L. Zultanski and Gregory C. Fu . 3 Grignard formation does not involve a radical chain mechanism. Formation of Alkanes and Arenes by Ring-forming Reactions. Produced grignard reagent react with with terminal hydrogen atoms of own grignard reagents's, alkyl halide Arash Ghaderi, Takanori Iwasaki, Asuka Fukuoka, Jun Terao, Nobuaki Kambe. Shintaro Kawamura, Kentaro Ishizuka, Hikaru Takaya, Masaharu Nakamura. Catalyst- and Solvent-Dependent Stereodivergence in the Intramolecular Et Andy M. Chapman, Mairi F. Haddow, and Duncan F. Wass . borane reagents). Ryley Kehoe, Markshun Mahadevan, Adeela Manzoor, Gillian McMurray, Patrick Wienefeld, Michael C. Baird, . ) Carbon–Bromine Bond Formation through a Nickel-Centered Spin-Crossing Mechanism. Stereoselective synthesis of a n Mixed AggregAte (MAA): A Single Concept for All Dipolar Organometallic Aggregates. Nickel-Catalyzed Kumada Coupling of Benzyl Chlorides and Vinylogous Derivatives. Nickel/Bis(oxazoline)-Catalyzed Asymmetric Kumada Reactions of Alkyl Electrophiles: Cross-Couplings of Racemic α-Bromoketones. ii Ulhas These metrics are regularly updated to reflect usage leading up to the last few days. Cross-Couplings Using Aryl Ethers via C–O Bond Activation Enabled by Nickel Catalysts. Rita Soler-Yanes, Manuel Guisán-Ceinos, Elena Buñuel, Diego J. Cárdenas. Cross-coupling of Grignard reagents with alkyl halides or tosylates by the use of nickel or palladium containing perovskite. Vineeta Soni, Rahul A. Jagtap, Rajesh G. Gonnade, and Benudhar Punji . Designs and Strategies for the Halo-Functionalization of Diazo Compounds. Diethyl ether can also be used but the subsequent alkyl lithium reagent must be used immediately after preparation due to an interaction with the solvent. Consider this retrosynthesis problem. Syntheses and Reactivities of Homo/HeteroMAAs. Annual Reports Section "A" (Inorganic Chemistry). Nickel-Catalyzed Diastereoselective Alkyl–Alkyl Kumada Coupling Reactions. Jimmy Coombs, Dalton Perry, Doo-Hyun Kwon, Christine M. Thomas. 3.04 Alkylations of Nonstabilized Carbanions. Alkynyl Grignards are unique among Grignards for their ability to do SN2 chemistry. Anionic Bismuth(III) chloride cluster with diselenide countercations: Application in C-S cross coupling reactions. the Altmetric Attention Score and how the score is calculated. Frustrated Lewis Pairs beyond the Main Group: Synthesis, Reactivity, and Small Molecule Activation with Cationic Zirconocene–Phosphinoaryloxide Complexes. Takuji Hatakeyama, Toru Hashimoto, Kalum K. A. D. S. Kathriarachchi, Takeshi Zenmyo, Hirofumi Seike, Masaharu Nakamura. Nickel-catalyzed dimerization of pyrrolidinoindoline scaffolds: systematic access to chimonanthines, folicanthines and (+)-WIN 64821. Apr 6, 2015 • ericminikel • Cambridge, MA • chem-20. This article is cited by Nickel-catalyzed cross-coupling of primary alkyl halides with phenylethynyl- and trimethylsilyethynyllithium reagents. K.S. sp3-sp3 Coupling reactions in the synthesis of natural products and biologically active molecules. Homocoupling of heteroaryl/aryl/alkyl Grignard reagents: I Stability and Unimolecular Reactivity of Palladate(II) Complexes [L Reductive Cross-Coupling of Conjugated Arylalkenes and Aryl Bromides with Hydrosilanes by Cooperative Palladium/Copper Catalysis. Oleg Vechorkin, Delphine Barmaz, Valérie Proust and Xile Hu. Stephen M. Goldup, David A. Leigh, Roy T. McBurney, Paul R. McGonigal, Andrew Plant. Oxidative Catalytic Coupling Reactions: Selective Formation of CC and CX Bonds Using Radical Processes. An Organometalllic NiIV Complex That Participates in Competing Transmetalation and C(sp2)–O Bond-Forming Reductive Elimination Reactions. Learn about our remote access options, Albert‐Ludwigs‐Universität Freiburg, Institut für Organische Chemie und Biochemie, Freiburg Institute for Advanced Studies (FRIAS), Albertstrasse 21, 79104 Freiburg (Germany) http://www.breit‐group.uni‐freiburg.de/. An efficient protocol for the synthesis of thioethers via iron-catalyzed cross-coupling reaction and its mechanistic investigation. Ruthenium-Catalyzed Regioselective Direct Alkylation of Arenes with Unactivated Alkyl Halides through CH Bond Cleavage. Synthesis of Allylic Alcohols via Cu-Catalyzed Hydrocarbonylative Coupling of Alkynes with Alkyl Halides. Copper-Catalyzed 1,5-Addition of Grignard reagents to Enantioenriched Donor-Acceptor Cyclopropanes with Inversion. Construction of Multiple, Contiguous Quaternary Stereocenters in Acyclic Molecules by Lithiation-Borylation. Tom Verhelst, Zuming Liu, Jens Maes, and Bert U. W. Maes . Ultrasonic activation of the arylation reaction of styrene catalyzed by transition metals. Masahiro Sai, Hideki Yorimitsu, Koichiro Oshima. − Ayoung Pyo, Yu Hyun Kim, Kyungho Park, Gwui Cheol Kim, Hyun Chul Choi, Sunwoo Lee. Hsin-Lun Kao, Chin-Keng Chen, Yu-Jen Wang, Chin-Fa Lee. Dhiab ATOUI, Khemais SAÏD, Ridha BEN SALEM.